Direct inhibition of cyclooxygenase-2 enzyme by an extract of Harpagophytum procumbens, harpagoside and harpagide
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Date
2011
Authors
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Publisher
Academic Journals
Abstract
A methanolic extract of Harpagophytum procumbens as well as harpagoside and harpagide were tested
as direct inhibitors of cyclooxygenase-2 enzyme (COX-2). The H. procumbens extract demonstrated
direct inhibition (68%) of COX-2 enzyme. The concentration of harpagoside and harpagide equivalent to
that found in the extract (3 and 1% respectively) contributed 1.5 and 13% to this inhibition. Results
indicated direct COX-2 enzyme inhibition by the H. procumbens extract due to possible synergistic
activity of active components in the extract, which include harpagide and harpagoside.
Description
Keywords
Pharmacy, Pharmacology, Harpagophytum procumbens, Harpagoside, Harpagide, Cylcooxygenase-2, Devils claw (Harpagophytum procumbens), Medicinal plants
Citation
Ebrahim, N. and Uebel, R.A. (2011). Direct inhibition of cyclooxygenase-2 enzyme by an
extract of Harpagophytum procumbens, harpagoside
and harpagide. African Journal of Pharmacy and Pharmacology, 5(20): 2209-2212