Direct inhibition of cyclooxygenase-2 enzyme by an extract of Harpagophytum procumbens, harpagoside and harpagide

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dc.contributor.authorEbrahim, Naushaad
dc.contributor.authorUebel, R.A.
dc.date.accessioned2016-06-14T13:47:09Z
dc.date.available2016-06-14T13:47:09Z
dc.date.issued2011
dc.description.abstractA methanolic extract of Harpagophytum procumbens as well as harpagoside and harpagide were tested as direct inhibitors of cyclooxygenase-2 enzyme (COX-2). The H. procumbens extract demonstrated direct inhibition (68%) of COX-2 enzyme. The concentration of harpagoside and harpagide equivalent to that found in the extract (3 and 1% respectively) contributed 1.5 and 13% to this inhibition. Results indicated direct COX-2 enzyme inhibition by the H. procumbens extract due to possible synergistic activity of active components in the extract, which include harpagide and harpagoside.en_US
dc.identifier.citationEbrahim, N. and Uebel, R.A. (2011). Direct inhibition of cyclooxygenase-2 enzyme by an extract of Harpagophytum procumbens, harpagoside and harpagide. African Journal of Pharmacy and Pharmacology, 5(20): 2209-2212en_US
dc.identifier.issn1996-0816
dc.identifier.urihttp://hdl.handle.net/10566/2326
dc.language.isoenen_US
dc.privacy.showsubmitterFALSE
dc.publisherAcademic Journalsen_US
dc.rights.uriAcademic Journals strongly supports the Open Access initiative. Abstracts and full texts of all articles published by Academic Journals are freely accessible to everyone immediately after publication.
dc.source.urihttp://dx.doi.org/10.5897/AJPP11.213
dc.status.ispeerreviewedTRUE
dc.subjectPharmacyen_US
dc.subjectPharmacologyen_US
dc.subjectHarpagophytum procumbensen_US
dc.subjectHarpagosideen_US
dc.subjectHarpagideen_US
dc.subjectCylcooxygenase-2en_US
dc.subjectDevils claw (Harpagophytum procumbens)en_US
dc.subjectMedicinal plantsen_US
dc.titleDirect inhibition of cyclooxygenase-2 enzyme by an extract of Harpagophytum procumbens, harpagoside and harpagideen_US
dc.typeArticleen_US

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