Alpha-glucosidase and alpha-amylase inhibitory activities, molecular docking, and antioxidant capacities of plectranthus ecklonii constituents
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
Shortage in insulin secretion or degradation of produced insulin is the principal characteristic of the metabolic disorder of diabetes mellitus (DM). However, because the current medications
for the treatment of DM have many detrimental side effects, it is necessary to develop more effective
antidiabetic drugs with minimal side effects. Alpha-glucosidase and alpha-amylase inhibitors are
directly implicated in the delay of carbohydrate digestion. Pharmacologically, these inhibitors could
be targeted for the reduction in glucose absorption rate and, subsequently, decreasing the postprandial rise in plasma glucose and the risk for long-term diabetes complications. The main objectives of
this research study were to isolate different phytochemical constituents present in the methanolic
extract of Plectranthus ecklonii and evaluate their alpha-glucosidase and alpha-amylase inhibitory
activities and antioxidant capacity.
Description
Keywords
Diabetes mellitus, Alpha-glucosidase, Oxidative stress, Alpha-amylase, Plectranthus ecklonii
Citation
Etsassala, N. G. E. R. et al. (2022). Alpha-glucosidase and alpha-amylase inhibitory activities, molecular docking, and antioxidant capacities of plectranthus ecklonii constituents. Antioxidants, 11(2), 378. https://doi.org/10.3390/antiox11020378