Alpha-glucosidase and alpha-amylase inhibitory activities, molecular docking, and antioxidant capacities of plectranthus ecklonii constituents

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dc.contributor.authorEtsassala, Ninon G. E. R.
dc.contributor.authorBadmus, Jelili A.
dc.contributor.authorIwuoha, Emmanuel. I.
dc.date.accessioned2022-07-07T12:36:47Z
dc.date.available2022-07-07T12:36:47Z
dc.date.issued2022
dc.description.abstractShortage in insulin secretion or degradation of produced insulin is the principal characteristic of the metabolic disorder of diabetes mellitus (DM). However, because the current medications for the treatment of DM have many detrimental side effects, it is necessary to develop more effective antidiabetic drugs with minimal side effects. Alpha-glucosidase and alpha-amylase inhibitors are directly implicated in the delay of carbohydrate digestion. Pharmacologically, these inhibitors could be targeted for the reduction in glucose absorption rate and, subsequently, decreasing the postprandial rise in plasma glucose and the risk for long-term diabetes complications. The main objectives of this research study were to isolate different phytochemical constituents present in the methanolic extract of Plectranthus ecklonii and evaluate their alpha-glucosidase and alpha-amylase inhibitory activities and antioxidant capacity.en_US
dc.identifier.citationEtsassala, N. G. E. R. et al. (2022). Alpha-glucosidase and alpha-amylase inhibitory activities, molecular docking, and antioxidant capacities of plectranthus ecklonii constituents. Antioxidants, 11(2), 378. https://doi.org/10.3390/antiox11020378en_US
dc.identifier.issn2076-3921
dc.identifier.urihttps://doi.org/10.3390/antiox11020378
dc.identifier.urihttp://hdl.handle.net/10566/7565
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectDiabetes mellitusen_US
dc.subjectAlpha-glucosidaseen_US
dc.subjectOxidative stressen_US
dc.subjectAlpha-amylaseen_US
dc.subjectPlectranthus eckloniien_US
dc.titleAlpha-glucosidase and alpha-amylase inhibitory activities, molecular docking, and antioxidant capacities of plectranthus ecklonii constituentsen_US
dc.typeArticleen_US

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