Determination of kanamycin plasma concentrations using LC/MS and pharmacokinetics of kanamycin in patients with multidrug-resistant tuberculosis and in patients with multidrug-resistant tuberculosis co-infected with HIV
| dc.contributor.advisor | Mugabo, Pierre | |
| dc.contributor.author | Abaniwonda, Ibukunoluwa Mercy | |
| dc.date.accessioned | 2014-10-23T12:50:12Z | |
| dc.date.accessioned | 2024-05-15T07:43:16Z | |
| dc.date.available | 2014-10-23T12:50:12Z | |
| dc.date.available | 2024-05-15T07:43:16Z | |
| dc.date.issued | 2012 | |
| dc.description | Magister Pharmaceuticae - MPharm | en_US |
| dc.description.abstract | The aim of the study was to determine firstly, kanamycin plasma concentrations using liquid chromatography coupled with mass spectrometry (LC/MS); secondly, to investigate the PK parameters of kanamycin in patients infected with MDR-TB and in patients co-infected with MDR-TB and HIV; thirdly, to assess the influence of HIV infection and renal impairment on the PK of kanamycin and fourthly, to find out whether there is any interaction between antiretroviral drugs and kanamycin. | en_US |
| dc.identifier.uri | https://hdl.handle.net/10566/15211 | |
| dc.language.iso | en | en_US |
| dc.publisher | University of the Western Cape | en_US |
| dc.rights.holder | University of the Western Cape | en_US |
| dc.subject | Multidrug-resistant tuberculosis | en_US |
| dc.subject | HIV | en_US |
| dc.subject | Liquid chromatography | en_US |
| dc.subject | Mass spectrometry | en_US |
| dc.subject | Pharmacokinetics | en_US |
| dc.subject | Plasma concentrations | en_US |
| dc.subject | Kanamycin | en_US |
| dc.title | Determination of kanamycin plasma concentrations using LC/MS and pharmacokinetics of kanamycin in patients with multidrug-resistant tuberculosis and in patients with multidrug-resistant tuberculosis co-infected with HIV | en_US |
| dc.type | Thesis | en_US |