Determination of kanamycin plasma concentrations using LC/MS and pharmacokinetics of kanamycin in patients with multidrug-resistant tuberculosis and in patients with multidrug-resistant tuberculosis co-infected with HIV
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Date
2012
Authors
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Journal ISSN
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Publisher
University of the Western Cape
Abstract
The aim of the study was to determine firstly, kanamycin plasma concentrations using liquid chromatography coupled with mass spectrometry (LC/MS); secondly, to investigate the PK parameters of kanamycin in patients infected with MDR-TB and in patients co-infected with MDR-TB and HIV; thirdly, to assess the influence of HIV infection and renal impairment on the PK of kanamycin and fourthly, to find out whether there is any interaction between antiretroviral drugs and kanamycin.
Description
Magister Pharmaceuticae - MPharm
Keywords
Multidrug-resistant tuberculosis, HIV, Liquid chromatography, Mass spectrometry, Pharmacokinetics, Plasma concentrations, Kanamycin