Patient-Control Association Study of the Leucine-Rich Repeat Kinase 2 (LRRK2) Gene in South African Parkinson's Disease Patients
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Date
2013
Journal Title
Journal ISSN
Volume Title
Publisher
National Institute of Health
Abstract
The leucine-rich repeat kinase 2 (LRRK2) gene is of interest to Parkinson's disease (PD) as it
has been implicated in both familial and sporadic forms of the disorder.1 PD-susceptibility
alleles in LRRK2 appear to be ethnic-specific with G2385R,2 R1628P3 and A419V4
identified in Asian populations, whereas M1646T is found in Caucasians.4 A haplotype
protecting against development of PD is present in Chinese (N551K-R1398H)5 and
Caucasians (N551K-R1398H-K1423K).4 Further studies are necessary to investigate the
contribution of LRRK2 to PD-susceptibility in various populations worldwide.
Description
Keywords
Parkinson’s disease, LRRK2 gene, Case-control association studies, South African population
Citation
Bardien, S. et al. (2013). Patient-Control Association Study of the Leucine-Rich Repeat Kinase 2 (LRRK2) Gene in South African Parkinson's Disease Patients. Movement Disorders, 28 (14): 1-4