Patient-Control Association Study of the Leucine-Rich Repeat Kinase 2 (LRRK2) Gene in South African Parkinson's Disease Patients

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dc.contributor.authorBardien, Soraya
dc.contributor.authorBlanckenberg, Janine
dc.contributor.authorvan der Merwe, Lize
dc.contributor.authorFarrer, Matthew J.
dc.contributor.authorRoss, Owen A.
dc.date.accessioned2017-07-10T09:14:07Z
dc.date.available2017-07-10T09:14:07Z
dc.date.issued2013
dc.description.abstractThe leucine-rich repeat kinase 2 (LRRK2) gene is of interest to Parkinson's disease (PD) as it has been implicated in both familial and sporadic forms of the disorder.1 PD-susceptibility alleles in LRRK2 appear to be ethnic-specific with G2385R,2 R1628P3 and A419V4 identified in Asian populations, whereas M1646T is found in Caucasians.4 A haplotype protecting against development of PD is present in Chinese (N551K-R1398H)5 and Caucasians (N551K-R1398H-K1423K).4 Further studies are necessary to investigate the contribution of LRRK2 to PD-susceptibility in various populations worldwide.en_US
dc.description.accreditationDepartment of HE and Training approved list
dc.identifier.citationBardien, S. et al. (2013). Patient-Control Association Study of the Leucine-Rich Repeat Kinase 2 (LRRK2) Gene in South African Parkinson's Disease Patients. Movement Disorders, 28 (14): 1-4en_US
dc.identifier.issn0885-3185
dc.identifier.urihttp://hdl.handle.net/10566/3058
dc.language.isoenen_US
dc.publisherNational Institute of Healthen_US
dc.rightsThis is the author-version of the article published online at: http://dx.doi.org/doi:10.1002/mds.25637
dc.source.urihttp://dx.doi.org/doi:10.1002/mds.25637
dc.subjectParkinson’s diseaseen_US
dc.subjectLRRK2 geneen_US
dc.subjectCase-control association studiesen_US
dc.subjectSouth African populationen_US
dc.titlePatient-Control Association Study of the Leucine-Rich Repeat Kinase 2 (LRRK2) Gene in South African Parkinson's Disease Patientsen_US
dc.typeArticleen_US

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