Synthesis & biological evaluation of neuroprotective molecules with polycyclic scaffolds

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dc.contributor.advisorMalan, Sarel F.
dc.contributor.advisorJoubert, Jacques
dc.contributor.authorSharma, Rajan
dc.date.accessioned2018-08-07T13:50:16Z
dc.date.accessioned2024-05-15T07:16:50Z
dc.date.available2018-08-07T13:50:16Z
dc.date.available2024-05-15T07:16:50Z
dc.date.issued2017
dc.descriptionDoctor Pharmaceuticae - Dpharm
dc.description.abstractAmong neurological disorders, many of the most devastating disorders are neurodegenerative. Modern research associates excitotoxicity to a variety of neuropathological conditions, suggesting that the neurodegenerative diseases with distinct etiologies may have excitotoxicity as a common pathway. Excitotoxicity occurs through over-stimulation of receptors for excitatory neurotransmitters like the N-methyl-D-aspartate (NMDA) receptors. Due to the relevance of NMDA receptors and excitotoxic processes, the antagonism or modulation of NMDA receptors is used as a therapeutic tool against neurodegenerative diseases. NMDA receptor activity can be modulated by S-nitrosylation and this modulation of NMDA receptor activity can be utilised in the development of neuroprotective drugs.
dc.identifier.urihttps://hdl.handle.net/10566/15056
dc.language.isoen
dc.publisherUniversity of the Western Cape
dc.rights.holderUniversity of the Western Cape
dc.subjectNeurodegenerative diseases
dc.subjectExcitotoxicity
dc.subjectApoptosis
dc.subjectPolycyclic cage compounds
dc.subjectDrug design
dc.subjectNeuroprotection
dc.subjectN-methyl-D-aspartate (NMDA) receptors
dc.subjectCalcium influx
dc.subjectNitric oxide
dc.subjectNO-donating
dc.subjectS-nitrosylation
dc.titleSynthesis & biological evaluation of neuroprotective molecules with polycyclic scaffolds

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