Synthesis & biological evaluation of neuroprotective molecules with polycyclic scaffolds
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Date
2017
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
University of the Western Cape
Abstract
Among neurological disorders, many of the most devastating disorders are
neurodegenerative. Modern research associates excitotoxicity to a variety of
neuropathological conditions, suggesting that the neurodegenerative diseases with
distinct etiologies may have excitotoxicity as a common pathway. Excitotoxicity
occurs through over-stimulation of receptors for excitatory neurotransmitters like
the N-methyl-D-aspartate (NMDA) receptors. Due to the relevance of NMDA
receptors and excitotoxic processes, the antagonism or modulation of NMDA
receptors is used as a therapeutic tool against neurodegenerative diseases. NMDA
receptor activity can be modulated by S-nitrosylation and this modulation of
NMDA receptor activity can be utilised in the development of neuroprotective
drugs.
Description
Doctor Pharmaceuticae - Dpharm
Keywords
Neurodegenerative diseases, Excitotoxicity, Apoptosis, Polycyclic cage compounds, Drug design, Neuroprotection, N-methyl-D-aspartate (NMDA) receptors, Calcium influx, Nitric oxide, NO-donating, S-nitrosylation