Identification of sub-clinical biomarkers that predict the risk of developing diabetic cardiomyopathy
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Date
2022
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
University of the Western Cape
Abstract
Cardiovascular disease (CVD) is the leading cause of death of people with obesity and type 2
diabetes (T2DM). According to a statistical report from the World Health Organization
(WHO), approximately 17.9 million people die annually because of CVD and diabetic
cardiomyopathy (DCM), a disease of the heart muscle occurring in the absence of coronary
artery disease or hypertension. Although not fully elucidated, the pathophysiology of DCM
includes myocardial left ventricular hypertrophy, impaired calcium handling, energy
metabolism, inflammation, apoptosis and myocardial fibrosis.
Description
Philosophiae Doctor - PhD
Keywords
Diabetes, Cardiovascular disease, Heart disease, Obesity, Biotechnology