Reduced glucose tolerance and skeletal muscle GLUT4 and IRS1 content in cyclists habituated to a long-term low-carbohydrate, high-fat diet
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Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
Human Kinetics Publishers Inc.
Abstract
Very little is known about how long-term (>6 months) adaptation to a low-carbohydrate, high-fat (LCHF) diet affects insulin
signaling in healthy, well-trained individuals. This study compared glucose tolerance; skeletal muscle glucose transporter 4
(GLUT4) and insulin receptor substrate 1 (IRS1) content; and muscle enzyme activities representative of the main energy
pathways (3-hydroxyacetyl-CoA dehydrogenase, creatine kinase, citrate synthase, lactate dehydrogenase, phosphofructokinase,
phosphorylase) in trained cyclists who followed either a long-term LCHF or a mixed-macronutrient (Mixed) diet. On separate
days, a 2-hr oral glucose tolerance test was conducted, and muscle samples were obtained from the vastus lateralis of fasted
participants.
Description
Keywords
Glucose clearance, Insulin signaling pathway, Ketogenic diet, Skeletal Muscle, Diet
Citation
Webster, C. C. et al. (2020). Reduced glucose tolerance and skeletal muscle GLUT4 and IRS1 content in cyclists habituated to a long-term low-carbohydrate, high-fat diet. International Journal of Sport Nutrition and Exercise Metabolism ,30(3), 210-217