Reduced glucose tolerance and skeletal muscle GLUT4 and IRS1 content in cyclists habituated to a long-term low-carbohydrate, high-fat diet

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dc.contributor.authorWebster, Christopher C
dc.contributor.authorvan Boom, Kathryn Merle
dc.contributor.authorArmin, Nur
dc.date.accessioned2020-11-11T08:03:25Z
dc.date.available2020-11-11T08:03:25Z
dc.date.issued2020
dc.description.abstractVery little is known about how long-term (>6 months) adaptation to a low-carbohydrate, high-fat (LCHF) diet affects insulin signaling in healthy, well-trained individuals. This study compared glucose tolerance; skeletal muscle glucose transporter 4 (GLUT4) and insulin receptor substrate 1 (IRS1) content; and muscle enzyme activities representative of the main energy pathways (3-hydroxyacetyl-CoA dehydrogenase, creatine kinase, citrate synthase, lactate dehydrogenase, phosphofructokinase, phosphorylase) in trained cyclists who followed either a long-term LCHF or a mixed-macronutrient (Mixed) diet. On separate days, a 2-hr oral glucose tolerance test was conducted, and muscle samples were obtained from the vastus lateralis of fasted participants.en_US
dc.identifier.citationWebster, C. C. et al. (2020). Reduced glucose tolerance and skeletal muscle GLUT4 and IRS1 content in cyclists habituated to a long-term low-carbohydrate, high-fat diet. International Journal of Sport Nutrition and Exercise Metabolism ,30(3), 210-217en_US
dc.identifier.issn1543-2742
dc.identifier.urihttp://hdl.handle.net/10566/5420
dc.identifier.uri10.1123/ijsnem.2019-0359
dc.language.isoenen_US
dc.publisherHuman Kinetics Publishers Inc.en_US
dc.subjectGlucose clearanceen_US
dc.subjectInsulin signaling pathwayen_US
dc.subjectKetogenic dieten_US
dc.subjectSkeletal Muscleen_US
dc.subjectDieten_US
dc.titleReduced glucose tolerance and skeletal muscle GLUT4 and IRS1 content in cyclists habituated to a long-term low-carbohydrate, high-fat dieten_US
dc.typeArticleen_US

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