Development and implementation of ontology-based systems for mammalian gene expression profiling
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Date
2009
Authors
Journal Title
Journal ISSN
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Publisher
University of the Western Cape
Abstract
The use of ontologies in the mapping of gene expression events provides an
effective and comparable method to determine the expression profile of an entire
genome across a large collection of experiments derived from different expression
sources. In this dissertation I describe the development of the developmental
human and mouse e voe ontologies and demonstrate the ontologies by
identifying genes showing a bias for developmental brain expression in human
and mouse, identifying transcription factor complexes, and exploring the mouse
orthologs of human cancer/testis genes.
Description
>Magister Scientiae - MSc
Keywords
Ontology, House development, Human development, Bioinformatics, Public health