Development and implementation of ontology-based systems for mammalian gene expression profiling

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dc.contributor.advisorHide, Winston
dc.contributor.authorKruger, Adele
dc.date.accessioned2023-06-12T09:00:26Z
dc.date.accessioned2024-05-17T07:20:08Z
dc.date.available2023-06-12T09:00:26Z
dc.date.available2024-05-17T07:20:08Z
dc.date.issued2009
dc.description>Magister Scientiae - MScen_US
dc.description.abstractThe use of ontologies in the mapping of gene expression events provides an effective and comparable method to determine the expression profile of an entire genome across a large collection of experiments derived from different expression sources. In this dissertation I describe the development of the developmental human and mouse e voe ontologies and demonstrate the ontologies by identifying genes showing a bias for developmental brain expression in human and mouse, identifying transcription factor complexes, and exploring the mouse orthologs of human cancer/testis genes.en_US
dc.identifier.urihttps://hdl.handle.net/10566/15232
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectOntologyen_US
dc.subjectHouse developmenten_US
dc.subjectHuman developmenten_US
dc.subjectBioinformaticsen_US
dc.subjectPublic healthen_US
dc.titleDevelopment and implementation of ontology-based systems for mammalian gene expression profilingen_US

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