Design of a thermoresponsive hydrogel for enhanced intratumoral permeation of a chemotherapeutic agent in oral squamous cell carcinoma
| dc.contributor.advisor | Aucamp, Marique | |
| dc.contributor.author | Tanga, Sandrine | |
| dc.date.accessioned | 2023-07-25T08:06:24Z | |
| dc.date.accessioned | 2024-05-15T07:42:41Z | |
| dc.date.available | 2023-07-25T08:06:24Z | |
| dc.date.available | 2024-05-15T07:42:41Z | |
| dc.date.issued | 2023 | |
| dc.description | Masters of Science | en_US |
| dc.description.abstract | Introduction: Oral squamous cell carcinoma is the most common and aggressive cancer occurring in the oral cavity. Intravenous chemotherapy remains a pivotal part of treatment for the disease; however, these drugs cause debilitating systemic side effects and are unable to permeate into the deep compact layers of tumorous tissue cells. Herein, the intratumoral delivery of doxorubicin using a novel hydrogel blend, of chitosan/k-carrageenan and PluronicTM F127, for a rapid solution-to-gel thermoresponsive transition at 37 °C is proposed to achieve tumour-specific delivery and controlled drug release. For enhanced permeation, a novel monoterpene – limonene with high lipophilicity and anti-cancer effect is combined with the hydrogel system. | en_US |
| dc.identifier.uri | https://hdl.handle.net/10566/15119 | |
| dc.language.iso | en | en_US |
| dc.publisher | University of the Western Cape | en_US |
| dc.rights.holder | University of the Western Cape | en_US |
| dc.subject | Chemotherapeutic drugs | en_US |
| dc.subject | Oral squamous cell carcinoma | en_US |
| dc.subject | Tumour | en_US |
| dc.subject | Cancer | en_US |
| dc.subject | Thermoresponsive hydrogel system | en_US |
| dc.title | Design of a thermoresponsive hydrogel for enhanced intratumoral permeation of a chemotherapeutic agent in oral squamous cell carcinoma | en_US |