Design of a thermoresponsive hydrogel for enhanced intratumoral permeation of a chemotherapeutic agent in oral squamous cell carcinoma

dc.contributor.advisorAucamp, Marique
dc.contributor.authorTanga, Sandrine
dc.date.accessioned2023-07-25T08:06:24Z
dc.date.accessioned2024-05-15T07:42:41Z
dc.date.available2023-07-25T08:06:24Z
dc.date.available2024-05-15T07:42:41Z
dc.date.issued2023
dc.descriptionMasters of Scienceen_US
dc.description.abstractIntroduction: Oral squamous cell carcinoma is the most common and aggressive cancer occurring in the oral cavity. Intravenous chemotherapy remains a pivotal part of treatment for the disease; however, these drugs cause debilitating systemic side effects and are unable to permeate into the deep compact layers of tumorous tissue cells. Herein, the intratumoral delivery of doxorubicin using a novel hydrogel blend, of chitosan/k-carrageenan and PluronicTM F127, for a rapid solution-to-gel thermoresponsive transition at 37 °C is proposed to achieve tumour-specific delivery and controlled drug release. For enhanced permeation, a novel monoterpene – limonene with high lipophilicity and anti-cancer effect is combined with the hydrogel system.en_US
dc.identifier.urihttps://hdl.handle.net/10566/15119
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectChemotherapeutic drugsen_US
dc.subjectOral squamous cell carcinomaen_US
dc.subjectTumouren_US
dc.subjectCanceren_US
dc.subjectThermoresponsive hydrogel systemen_US
dc.titleDesign of a thermoresponsive hydrogel for enhanced intratumoral permeation of a chemotherapeutic agent in oral squamous cell carcinomaen_US

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