Department of Maxillo-Facial & Oral Surgery

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Browsing by Subject "Ameloblastoma"

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    Ameloblastoma of the mandible: A radiological and clinical study at the University of the Western Cape Oral Health Centre
    (University of the Western Cape, 2019) Ranchod, Sanjay; Morkel, Jean
    Ameloblastoma is the most common benign tumour of odontogenic origin and presents five times more in the mandible than in the maxilla (Reichardt et al. 1995). Although benign, it exhibits an invasive behavioural growth pattern with a high rate of recurrence if not managed appropriately. Ameloblastoma occurs in all age groups, but is most common in patients between the ages of 20 and 40 years. Males and females are equally affected. Clinically, ameloblastoma presents as a slow-growing, painless tumour, which if left untreated, can grow to enormous proportions. Radiographically, the lesion presents as either multilocular or unilocular radiolucency. The internal appearance of multilocular lesions may resemble a soap-bubble, honeycomb or spider-like pattern. Combinations of these patterns are not unusual.
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    Clinicopathological profile of ameloblastomas among Sudanese patients
    (University of the Western Cape, 2024) Mashail Mahmoud Hamid; Manogari Chetty
    Background: Ameloblastoma is considered the most common benign epithelial odontogenic tumor with a high rate of recurrence if not removed adequately. Knowledge of early events leading to and promoting tumorigenesis in ameloblastoma remains limited, partly because studies directed at identifying molecular factors and events that initiate, and drive tumorigenesis are inconclusive. Exploring the genetic aspects and correlating that to the biological behavior of ameloblastoma and its subtypes in a big sample size may help predict the clinical behavior and prognosis to embark on the most suitable treatment protocol. Moreover, it can objectively assess post-therapeutic response, particularly in recurrent cases of ameloblastoma. Many epidemiological studies on ameloblastoma have been conducted worldwide, however, despite the high frequency and aggressive behavior of this tumor in Sudan, there are no recent published reports regarding the prevalence of ameloblastoma, even though many patients are diagnosed and treated at Khartoum Teaching Dental Hospital (the main OMS referral hospital in Sudan). Most of these patients present with large-sized aggressive tumors with massive bone destruction and soft tissue invasion; cases with recurrence and malignant transformation are often seen there as well. Moreover, several markers and genes involved in the pathogenesis of ameloblastoma have been investigated worldwide; however, no similar studies have been conducted in Sudan, therefore, further investigation and studies in this field are needed.
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    Unicystic ameloblastoma: A critical appraisal
    (2000) Singh, Suvir; Shear, M
    Robinson and Martinez first introduced the entity of unicystic ameloblastoma in 1977. Since then numerous case reports and series have been published. The evidence suggests that a more conservative approach can be used successfully to treat the unicystic ameloblastoma. The term unicystic is derived from the macro- and microscopic appearance of the lesion, whereas the term unilocular is used in radiological interpretation to describe a radiolucency having one loculus or compartment. Much confusion stems from the fact that a unicystic ameloblastoma might appear not only as a unilocular lesion, but also as what is often interpreted as a multilocular bone defect.