Magister Pharmaceuticae - MPharm

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https://hdl.handle.net/10566/14969

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Browsing by Author "Aucamp, Marique"

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    Design of a thermoresponsive hydrogel for enhanced intratumoral permeation of a chemotherapeutic agent in oral squamous cell carcinoma
    (University of the Western Cape, 2023) Tanga, Sandrine; Aucamp, Marique
    Introduction: Oral squamous cell carcinoma is the most common and aggressive cancer occurring in the oral cavity. Intravenous chemotherapy remains a pivotal part of treatment for the disease; however, these drugs cause debilitating systemic side effects and are unable to permeate into the deep compact layers of tumorous tissue cells. Herein, the intratumoral delivery of doxorubicin using a novel hydrogel blend, of chitosan/k-carrageenan and PluronicTM F127, for a rapid solution-to-gel thermoresponsive transition at 37 °C is proposed to achieve tumour-specific delivery and controlled drug release. For enhanced permeation, a novel monoterpene – limonene with high lipophilicity and anti-cancer effect is combined with the hydrogel system.
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    An investigation into combined amorphous form of sufadoxine, pyrimethamine and azithromycin
    (University of Western Cape, 2021) Okello, Geoffrey; Aucamp, Marique
    Malaria remains one of the top mortality causes in the sub-Saharan African region, especially among pregnant women and infants. Despite several measures being implemented within the affected areas such as the use of treated mosquito nets, sulfadoxine and pyrimethamine (SULPYR) as an intermittent preventive treatment (IPTp-SP) is still considered the standard prophylactic regimen for pregnant women. Recently, the WHO increased the regimen of IPTp- SP from three to four doses on a monthly interval, this recommendation poses a potential risk of toxicity and resistance to the drugs. An improvement towards this challenge is under clinical trial and consists of the inclusion of azithromycin (AZI), a macrolide antibiotic, to the current IPTp-SP treatment regimen. This will not only aid in the prophylaxis of malaria in pregnant women but will also assist in other pregnancy related infections. All three these drugs exhibit poor aqueous solubility; requiring high concentrations for oral administration to achieve therapeutic plasma concentrations.
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    The physicochemical characterisation, compatibility testing and solid-state form screening of terizidone - Pyridoxine combinations
    (University of Western Cape, 2021) Musafili, Ngabo Yves; Aucamp, Marique
    Terizidone (TZD) is considered an essential anti-tuberculosis drug and in South Africa it is prescribed as part of the multi-drug resistant tuberculosis (MDR-TB) treatment regimen. From a literature study it became apparent that very little is known in terms of the physicochemical characteristics of TZD and only one literature source mentions one polymorphic form of this drug. Furthermore, it exhibits neurotoxicity as an adverse effect, leading to the concomitant administration of pyridoxine (PDX) to counteract the TZD-induced side effects. MDR-TB patients experience major side effects from taking the drug for a long period (18 months) and it often results in resistance and poor adherence. This study therefore focused on the possibility to combine TZD and PDX either as co-crystals or as co-amorphous solid-state forms. In order to achieve this a complete physicochemical profile of TZD was determined, since very limited information could be found in literature.