The physicochemical characterisation, compatibility testing and solid-state form screening of terizidone - Pyridoxine combinations
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Date
2021
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
University of Western Cape
Abstract
Terizidone (TZD) is considered an essential anti-tuberculosis drug and in South
Africa it is prescribed as part of the multi-drug resistant tuberculosis (MDR-TB) treatment
regimen. From a literature study it became apparent that very little is known in terms of the
physicochemical characteristics of TZD and only one literature source mentions one
polymorphic form of this drug. Furthermore, it exhibits neurotoxicity as an adverse effect,
leading to the concomitant administration of pyridoxine (PDX) to counteract the TZD-induced
side effects. MDR-TB patients experience major side effects from taking the drug for a long
period (18 months) and it often results in resistance and poor adherence. This study therefore
focused on the possibility to combine TZD and PDX either as co-crystals or as co-amorphous
solid-state forms. In order to achieve this a complete physicochemical profile of TZD was
determined, since very limited information could be found in literature.
Description
Magister Pharmaceuticae - MPharm
Keywords
Tuberculosis, Terizidone, South Africa, Drug compatibility