Conference Papers and Reports

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Browsing by Author "Chetty, Manogari"

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    CranDentSA registry: Advancing orodental and craniofacial anomalies research in South Africa
    (University of the Western Cape, 2024) Roomaney, Imaan Amina; Kabbashi, Salma; Chetty, Manogari
    “A dental anomalies registry is crucial for advancing the field by providing essential epidemiological data and guiding future research, diagnosis, and treatment of dental and other developmental disorders.” Dental anomalies are often associated with rare diseases and reflect pathological events intrinsic to tooth development or secondary systemic dysregulation. Dental anomalies can aid in the diagnosis of rare diseases and may share a common aetiopathogenesis to rare diseases. The lack of data available in South Africa hampers comprehensive understanding and effective management. The CranDentSA Registry aims to establish a patient-centric database to document and monitor orodental and craniofacial anomalies in South Africa. The registry will aid in understanding the epidemiology, enhance phenotype delineation, assess impact, evaluate the management of these anomalies, enhance patient care, facilitate interdisciplinary collaboration, and contribute to global research efforts.
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    Radiographic patterns of sella turcica shape in osteogenesis imperfecta: A pilot study in a South African cohort
    (University of the Western Cape, 2025) Roomaney, Imaan Amina; Walters, J; Chetty, Manogari
    Background: The sella turcica (ST), a readily identifiable structure on lateral cephalograms and cone beam computed tomography (CBCTs), is important in dental and craniofacial assessment. Osteogenesis imperfecta (OI) is associated with cranial base abnormalities, including distinct radiographic ST shapes. Patterns of ST morphology are relevant in understanding the pathophysiology of the neurocranium. The anterior part is derived from neural crest cells, and the posterior wall cartilage develops under the influence of the notochord. Results: Eighteen OI patients were included, fifteen of whom were diagnosed with OI type 3 (OI3), with eleven (73%) confirmed to have pathogenic variants in FKBP10. Figure 1 provides examples of STs identified in this study. Figure 2 provides statistical findings. Statistical analysis revealed no significant difference in ST shape distribution between OI1 and OI3 subtypes.