Diagnostic approaches of pneumonia for commercial-scale biomedical applications: An overview
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Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis
Abstract
Pneumonia remains the leading infectious cause of death among children under five years of age,
and the elderly. Several biomarkers, which have been identified for its diagnosis lack specificity, as
they could not differentiate viral from bacterial pathogens of the disease; these biomarkers also fail to
establish a distinction between pneumonia and other associated diseases such as pulmonary tuberculosis and Human Immunodeficiency Virus (HIV). This review outlined the menace of pneumonia
disease from the statistical prevalence, clinical and immunological view, challenges with the methods used in diagnosis, and more useful information about methods of diagnosis of pneumonia with
their limitations as well. Additionally, the use of aptamers and antimicrobial peptides (AMPs) rather
than antibodies to bind and recognize receptors for diagnostics, offers several advantages over other
biomarkers shortcomings such as non-specificity.
Description
Keywords
Pneumonia, Aptamers, Antimicrobial peptides, Biomarkers, Bioinformatics
Citation
Bakare, O. O. et al. (2020). Diagnostic approaches of pneumonia for commercial-scale biomedical applications: An overview. All Life ,13(1), 532-547