Application on gold nanoparticles-dotted 4-nitrophenylazo graphene in a label-free impedimetric deoxynivalenol immunosensor

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dc.contributor.advisorSunday, Christopher Edozie
dc.contributor.advisorMasikini, Malua
dc.contributor.advisorWilson, Lindsay
dc.contributor.advisorRassie, Candice
dc.contributor.advisorWaryo, Tesfaye T.
dc.contributor.advisorBaker, Priscilla
dc.contributor.advisorIwuoha, Emmanuel I.
dc.date.accessioned2017-01-30T13:38:20Z
dc.date.available2017-01-30T13:38:20Z
dc.date.issued2015
dc.description.abstractIn this paper, we report a new concept to construct a label-free electrochemical inhibition-based immunosensor for the detection of the mycotoxin deoxynivalenol (DON) in cereal samples. The electrochemical impedance spectroscopy of tris(bipyridine) ruthenium (II) chloride was used as a marker enhanced with gold nanoparticles-dotted 4-nitrophenylazo functionalized graphene (AuNp/G/PhNO2) nanocatalyst mediated in Nafion on a glassy carbon electrode. Under the optimized conditions, the formation of immunocomplexes inhibited electron flow and increased the charge transfer resistance of the sensing interface linearly. The change in impedance was proportional to DON concentrations in the range of 6–30 ng/mL with a sensitivity and detection limit of 32.14 ΩL/ng and 0.3 µg/mL, respectively, which compares favorably with the ELISA result. The proposed sensor had a stability of 80.3%, good precision and selectivity in DON standard solution containing different interfering agents, indicating promising application prospect for this strategy in designing impedimetric, electrochemiluminescent, voltammetric or amperometric sensors.en_US
dc.identifier.citationSunday, C. E. (2015). Application on gold nanoparticles-dotted 4-nitrophenylazo graphene in a label-free impedimetric deoxynivalenol immunosensor. Sensors, 15:3854-3871en_US
dc.identifier.issn1424-8220
dc.identifier.urihttp://hdl.handle.net/10566/2506
dc.identifier.urihttp://dx.doi.org/10.3390/s150203854
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rightsAll articles published by MDPI are made immediately available worldwide under an open access license
dc.subjectDeoxynivalenolen_US
dc.subjectMycotoxinen_US
dc.subjectGrapheneen_US
dc.subjectImmunosensoren_US
dc.subjectGraphene oxideen_US
dc.subjectNafionen_US
dc.titleApplication on gold nanoparticles-dotted 4-nitrophenylazo graphene in a label-free impedimetric deoxynivalenol immunosensoren_US
dc.typeArticleen_US

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