The effect of co-crystallization and polymorphism on the physicochemical properties of amoxicillin tri-hydrate
| dc.contributor.advisor | Samsodien, Halima | |
| dc.contributor.author | Jaaida, Nesren Al-Hadi | |
| dc.date.accessioned | 2016-07-19T09:05:18Z | |
| dc.date.accessioned | 2024-05-15T07:42:34Z | |
| dc.date.available | 2016-07-19T09:05:18Z | |
| dc.date.available | 2024-05-15T07:42:34Z | |
| dc.date.issued | 2013 | |
| dc.description | Magister Pharmaceuticae - MPharm | en_US |
| dc.description.abstract | Many active pharmaceutical ingredients (APIs) have poor physicochemical properties such as solubility, dissolution and chemical stability. Several strategies are used to enhance and improve these properties of the API. Co-crystallization and polymorphism studies are possible strategy used in pre-formulation studies to optimize these properties of the drug without modifying its pharmacological effect. The purpose of this research was to investigate the polymorphism and co-crystallization effects of the penicillin-type antibiotic, amoxicillin tri-hydrate. Several techniques such as: slow evaporation, slow cooling, vapour diffusion, sublimation, grinding and solvent assisted grinding was employed. In producing co-crystals, the API was non-covalently bound to selected co-formers such as: saccharin, nicotinamide, salicylic acid, L-tartaric acid, D-tartaric acid, L-aspartic acid, stearic acid, benzoic anhydride, oxalic acid di-hydrate, cinnamic acid, succinic acid and citric acid monohydrate. Nine co-crystals of amoxicillin tri-hydrate had been formed. Differential scanning calorimetry (DSC), hot stage microscopy (HSM) and thermal gravimetric analysis (TGA) was conducted to analyse the thermal behaviour of the co-crystals. Powder X-ray diffraction (PXRD) and spectroscopic techniques [infra-red (FTIR) and H1-nuclear magnetic resonance (H1MNR)] were employed for screening of the co-crystal forms. Furthermore, dissolution testing was conducted to investigate the application of the newly derivatised forms. | en_US |
| dc.identifier.uri | https://hdl.handle.net/10566/15093 | |
| dc.language.iso | en | en_US |
| dc.publisher | University of the Western Cape | en_US |
| dc.rights.holder | University of the Western Cape | en_US |
| dc.subject | Co-crystallization | en_US |
| dc.subject | X-ray diffraction | en_US |
| dc.subject | Amoxicillin tri-hydrate | en_US |
| dc.subject | Dissolution | en_US |
| dc.title | The effect of co-crystallization and polymorphism on the physicochemical properties of amoxicillin tri-hydrate | en_US |
| dc.type | Thesis | en_US |