Adult medical emergency unit presentations due to adverse drug reactions in a setting of high HIV prevalence
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Date
2021
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
African Federation for Emergency Medicine
Abstract
South Africa has the world's largest antiretroviral treatment programme, which may contribute to the adverse drug reaction (ADR) burden. We aimed to determine the proportion of adult non-trauma emergency unit (EU) presentations attributable to ADRs and to characterise ADR-related EU presentations, stratified according to HIV status, to determine the contribution of drugs used in management of HIV and its complications to ADR-related EU presentations, and identify factors associated with ADR-related EU presentation. Methods: We conducted a retrospective folder review on a random 1.7% sample of presentations over a 12-month period in 2014/2015 to the EUs of two hospitals in Cape Town, South Africa. We identified potential ADRs with the help of a trigger tool. A multidisciplinary panel assessed potential ADRs for causality, severity, and preventability.
Description
Keywords
Adverse drug reaction, Emergency department, HIV, Prevalence, South Africa
Citation
Igumbor, E. et al. (2021). Adult medical emergency unit presentations due to adverse drug reactions in a setting of high HIV prevalence. African Journal of Emergency Medicine ,11(1), 46-52