Exploring the utility of a spontaneous adverse drug reaction reporting system in identifying drug–drug interactions between antiretrovirals, antitubercular drugs, and cotrimoxazole: a case/non-case analysis

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dc.contributor.authorKhoza, Star
dc.contributor.authorMasuka, Josiah Tatenda
dc.contributor.authorMosam, Anisa
dc.date.accessioned2021-01-04T09:47:39Z
dc.date.available2021-01-04T09:47:39Z
dc.date.issued2020
dc.description.abstractBackground: Drug–drug interactions (DDIs) cause significant morbidity and mortality, especially in patients with HIV with opportunistic infections such as tuberculosis. However, the literature on quantitative signal detection analyses for DDIs within the national spontaneous reporting systems (SRSs) of countries with high HIV/tuberculosis burdens is lacking. Objective: Our objective was to explore the utility of using post-marketing SRSs in quantitative signal detection analyses of DDIs. Methods: A case/non-case analysis using the Zimbabwean adverse drug reaction (ADR) database obtained from VigiBase® was utilized for quantitative signal detection using 2 × 2 contingency table calculations. Cases were defined as individual case safety reports (ICSRs) with the ADR of interest, and non-cases included the rest of the ICSRs.en_US
dc.identifier.citationKhoza, S. et a. (2020). Exploring the utility of a spontaneous adverse drug reaction reporting system in identifying drug–drug interactions between antiretrovirals, antitubercular drugs, and cotrimoxazole: a case/non-case analysis. Drugs and Therapy Perspectives 36(12), 583-589en_US
dc.identifier.issn1179-1977
dc.identifier.urihttps://doi.org/10.1007/s40267-020-00779-x
dc.identifier.urihttp://hdl.handle.net/10566/5533
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.subjectDrug–drug interactions (DDIs)en_US
dc.subjectHIV/tuberculosisen_US
dc.subjectPatientsen_US
dc.subjectDrug reaction reporting systemen_US
dc.subjectAntiretroviralsen_US
dc.titleExploring the utility of a spontaneous adverse drug reaction reporting system in identifying drug–drug interactions between antiretrovirals, antitubercular drugs, and cotrimoxazole: a case/non-case analysisen_US
dc.typeArticleen_US

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