Associations between human leukocyte antigen class I variants and the Mycobacterium tuberculosis subtypes causing disease

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dc.contributor.authorSalie, Muneeb
dc.contributor.authorvan der Merwe, Lize
dc.contributor.authorMöller, Marlo
dc.contributor.authorDaya, Michelle
dc.contributor.authorvan der Spuy, Gian D.
dc.contributor.authorvan Helden, Paul D.
dc.contributor.authorMartin, Maureen P.
dc.contributor.authorGao, Xiao-jiang
dc.contributor.authorWarren, Robin M.
dc.contributor.authorCarrington, Mary
dc.contributor.authorHoal, Eileen G.
dc.date.accessioned2018-01-19T12:18:29Z
dc.date.available2018-01-19T12:18:29Z
dc.date.issued2013
dc.description.abstractBACKGROUND. The development of active tuberculosis disease has been shown to be multifactorial. Interactions between host and bacterial genotype may influence disease outcome, with some studies indicating the adaptation of M. tuberculosis strains to specific human populations. Here we investigate the role of the human leukocyte antigen (HLA) class I genes in this biological process. METHODS. Three hundred patients with tuberculosis from South Africa were typed for their HLA class I alleles by direct sequencing. Mycobacterium tuberculosis genotype classification was done by IS6110 restriction fragment length polymorphism genotyping and spoligotyping. RESULTS. We showed that Beijing strain occurred more frequently in individuals with multiple disease episodes (P < .001) with the HLA-B27 allele lowering the odds of having an additional episode (odds ratio, 0.21; P = .006). Associations were also identified for specific HLA types and disease caused by the Beijing, LAM, LCC, and Quebec strains. HLA types were also associated with disease caused by strains from the Euro-American or East Asian lineages, and the frequencies of these alleles in their sympatric human populations identified potential coevolutionary events between host and pathogen. CONCLUSIONS. This is the first report of the association of human HLA types and M. tuberculosis strain genotype, highlighting that both host and pathogen genetics need to be taken into consideration when studying tuberculosis disease development.en_US
dc.description.accreditationWeb of Science
dc.identifier.citationSalie, M. et al. (2013). Associations between human leukocyte antigen class I variants and the Mycobacterium tuberculosis subtypes causing disease. The Journal of Infectious Diseases, 209: 216 – 223en_US
dc.identifier.issn0022-1899
dc.identifier.urihttp://dx.doi.org/10.1093/infdis/jit443
dc.identifier.urihttp://hdl.handle.net/10566/3403
dc.language.isoenen_US
dc.privacy.showsubmitterFALSE
dc.publisherOxford University Pressen_US
dc.rightsThis is the author-version of the article published online at: http://dx.doi.org/10.1093/infdis/jit443
dc.status.ispeerreviewedTRUE
dc.subjectMycobacterium tuberculosisen_US
dc.subjectTuberculosisen_US
dc.subjectHuman leukocyte antigensen_US
dc.subjectHost–pathogenen_US
dc.subjectCoadaptationen_US
dc.subjectSusceptibilityen_US
dc.titleAssociations between human leukocyte antigen class I variants and the Mycobacterium tuberculosis subtypes causing diseaseen_US
dc.typeArticleen_US

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