Structural and molecular docking analytical studies of the predicted ligand binding sites of cadherin-1 in cancer prognostics

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dc.contributor.authorBakare, Olalekan Olanrewaju
dc.contributor.authorKeyster, Marshall
dc.contributor.authorFadaka, Adewale Oluwaseun
dc.date.accessioned2020-11-23T10:53:45Z
dc.date.available2020-11-23T10:53:45Z
dc.date.issued2020
dc.description.abstractSeveral studies have explored the design of antimicrobial peptides (AMPs) for the development of therapeutic and diagnostic molecules for the treatment and identification of pathogenic diseases as well as cancer. Human cadherin-1 protein has been identified to be involved in adhesion-mediated signalling pathways in normal cells and its loss through genetic and epigenetic alterations can result in an enhanced invasion and metastasis of malignancy in tumours. Therefore, the identification of cadherin during treatment of cancer can be used as prognostic biomarker to establish the responsiveness of patients to treatment regimen. Antimicrobial peptides (AMPs) offer several compensatory advantages in biomedical applications and have been used for treatment of diseases, dietary supplements and diagnosis of diseases. The aim of this research work was to use in silico approaches to analyse retrieved human cadherin-1 as prognostic targets in cancer treatments using modelled putative anticancer AMPs.en_US
dc.identifier.citationBakare, O. O. et al. (2020). Structural and molecular docking analytical studies of the predicted ligand binding sites of cadherin-1 in cancer prognostics.Advances and Applications in Bioinformatics and Chemistry, 13, 1-9en_US
dc.identifier.issn1178-6949
dc.identifier.urihttps://doi.org/10.2147/AABC.S253851
dc.identifier.urihttp://hdl.handle.net/10566/5463
dc.language.isoenen_US
dc.publisherDove Medical Pressen_US
dc.subjectCanceren_US
dc.subjectAntimicrobial peptidesen_US
dc.subjectPrognosisen_US
dc.subjectHomologyen_US
dc.subjectModellingen_US
dc.titleStructural and molecular docking analytical studies of the predicted ligand binding sites of cadherin-1 in cancer prognosticsen_US
dc.typeArticleen_US

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