Structural and molecular docking analytical studies of the predicted ligand binding sites of cadherin-1 in cancer prognostics
Loading...
Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
Dove Medical Press
Abstract
Several studies have explored the design of antimicrobial peptides (AMPs) for the
development of therapeutic and diagnostic molecules for the treatment and identification of
pathogenic diseases as well as cancer. Human cadherin-1 protein has been identified to be involved
in adhesion-mediated signalling pathways in normal cells and its loss through genetic and
epigenetic alterations can result in an enhanced invasion and metastasis of malignancy in tumours.
Therefore, the identification of cadherin during treatment of cancer can be used as prognostic
biomarker to establish the responsiveness of patients to treatment regimen. Antimicrobial peptides
(AMPs) offer several compensatory advantages in biomedical applications and have been used for
treatment of diseases, dietary supplements and diagnosis of diseases. The aim of this research work
was to use in silico approaches to analyse retrieved human cadherin-1 as prognostic targets in
cancer treatments using modelled putative anticancer AMPs.
Description
Keywords
Cancer, Antimicrobial peptides, Prognosis, Homology, Modelling
Citation
Bakare, O. O. et al. (2020). Structural and molecular docking analytical studies of the predicted ligand binding sites of cadherin-1 in cancer prognostics.Advances and Applications in Bioinformatics and Chemistry, 13, 1-9