Use of a rat ex-vivo testis culture method to assess toxicity of select known male reproductive toxicants

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dc.contributor.authorGoldstein, Keith M.
dc.contributor.authorSeyler, David E.
dc.contributor.authorBaker, Thomas K.
dc.date.accessioned2023-04-13T10:19:14Z
dc.date.available2023-04-13T10:19:14Z
dc.date.issued2016
dc.description.abstractDue to the complex physiology of the testes, in vitro models have been largely unsuccessful at modeling testicular toxicity in vivo. We conducted a pilot study to evaluate the utility of the Durand ex vivo rat seminiferous tubule culture model [1], [2], [3] that supports spermatogenesis through meiosis II, including the formation of round spermatids. We used this system to evaluate the toxicity of four known testicular toxicants: 1,3-dinitrobenzene (DNB), 2-methoxyacetic acid (MAA), bisphenol A (BPA), and lindane over 21 days of culture.en_US
dc.identifier.citationGoldstein, K. M. et al. (2016). Use of a rat ex-vivo testis culture method to assess toxicity of select known male reproductive toxicants. Reproductive Toxicology, 60, 92-103. https://doi.org/10.1016/j.reprotox.2016.01.003en_US
dc.identifier.issn0890-6238
dc.identifier.urihttps://doi.org/10.1016/j.reprotox.2016.01.003
dc.identifier.urihttp://hdl.handle.net/10566/8778
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectDinitrobenzeneen_US
dc.subjectMethoxyaceticen_US
dc.subjectTesticular toxicityen_US
dc.subjectBioscienceen_US
dc.titleUse of a rat ex-vivo testis culture method to assess toxicity of select known male reproductive toxicantsen_US
dc.typeArticleen_US

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