An investigation into the role of histological parameters in the prediction of the prognosis for tl and t2 oral squamous cell carcinomas
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Date
1998
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
University of Western Cape
Abstract
TI and T2 squamous cell carcinomas of the head and neck have an unpredictable prognosis that
often pose therapeutic problems. Sophisticated methods such as cytometric DNA analysis,
immunocytochemistry and detection of cellular growth factors, have been applied with varying
success rates for predicting recurrences, metastatic rates and overall prognoses. However, with
the general lack of resources in Africa, devising a simple, reliable, reproducible and cost-effective
method of predicting tumour behaviour to aid optimal treatment planning is imperative. Surgical
excision specimens of forty-eight primary Tl and T2 squamous cell carcinomas of the floor of the
mouth and tongue were histologically evaluated by two individual pathologists (double-blinded
study) who had no prior knowledge of clinical course or outcome.
Description
Magister Chirurgiae Dentium (MChD)
Keywords
Africa, Tumour behaviour, Nuclear aberration, treatment failure