Association between pro-inflammatory alleles and allergic phenotypes in Xhosa adolescents

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dc.contributor.authorLaurence, Craig
dc.contributor.authorvan der Merwe, Lize
dc.contributor.authorZhang, Guicheng
dc.contributor.authorLe Souef, Peter
dc.contributor.authorLevin, Michael
dc.date.accessioned2018-05-15T11:40:31Z
dc.date.available2018-05-15T11:40:31Z
dc.date.issued2018
dc.description.abstractBACKGROUND: Significant differences exist in the prevalence, spectrum, and severity of allergic diseases between developing and developed countries and between subpopulations within single countries. These discrepancies likely result from a complex interaction between genetic and environmental factors. However, the precise nature of the contribution of ethnicity to genetic differences in the predisposition to allergic disease is not yet fully understood. In particular, there is a paucity of literature regarding the genetic determinants of allergic disease in people of black African origin with little or no genetic admixture. OBJECTIVE: We aimed to analyze associations between 27 single nucleotide polymorphisms (SNPs) and allergy phenotypes in the local Xhosa population. METHODS: A convenience sample of 213 Xhosa teenagers was enrolled at a local high school. Phenotypic data were collected in the form of a symptom questionnaire, skin prick tests for common food and aeroallergens, total serum IgE, and IgE to Ascaris lumbricoides. In addition, genotyping was performed to establish the prevalence of putative pro-inflammatory alleles. RESULTS: We demonstrated several significant associations between polymorphisms and allergy phenotypes. In particular, 2 polymorphisms in the IL-10 gene (IL10 -592A> C and IL10 -1082A> G) and 1 in the IL-4 gene (IL4 -589C> T) showed multiple associations with allergic sensitization and asthma phenotypes. Other polymorphisms, across a multitude of genes with discrepant functions, showed less consistent associations. CONCLUSION: This study represents an important first step in genotype/phenotype association in this population. Further research is required to confirm or refute our findings.en_US
dc.identifier.citationLaurence, C. et al. (2018). Association between pro-inflammatory alleles and allergic phenotypes in Xhosa adolescents. Pediatric Allergy Immunology, 29: 311–317.en_US
dc.identifier.issn0905-6157
dc.identifier.urihttp://dx.doi.org/10.1111/pai.12859
dc.identifier.urihttp://hdl.handle.net/10566/3671
dc.language.isoenen_US
dc.privacy.showsubmitterFALSE
dc.publisherWileyen_US
dc.rightsThis is the author-version of the article published online at: http://dx.doi.org/10.1111/pai.12859
dc.status.ispeerreviewedTRUE
dc.subjectAfricanen_US
dc.subjectAllergyen_US
dc.subjectAssociationen_US
dc.subjectAsthmaen_US
dc.subjectIL-10en_US
dc.subjectIL-4en_US
dc.subjectPolymorphismen_US
dc.subjectXhosaen_US
dc.titleAssociation between pro-inflammatory alleles and allergic phenotypes in Xhosa adolescentsen_US
dc.typeArticleen_US

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