Radiographic patterns of sella turcica shape in osteogenesis imperfecta: A pilot study in a South African cohort

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dc.contributor.authorRoomaney, Imaan Amina
dc.contributor.authorWalters, J
dc.contributor.authorChetty, Manogari
dc.date.accessioned2025-08-11T13:40:19Z
dc.date.available2025-08-11T13:40:19Z
dc.date.issued2025
dc.description.abstractBackground: The sella turcica (ST), a readily identifiable structure on lateral cephalograms and cone beam computed tomography (CBCTs), is important in dental and craniofacial assessment. Osteogenesis imperfecta (OI) is associated with cranial base abnormalities, including distinct radiographic ST shapes. Patterns of ST morphology are relevant in understanding the pathophysiology of the neurocranium. The anterior part is derived from neural crest cells, and the posterior wall cartilage develops under the influence of the notochord. Results: Eighteen OI patients were included, fifteen of whom were diagnosed with OI type 3 (OI3), with eleven (73%) confirmed to have pathogenic variants in FKBP10. Figure 1 provides examples of STs identified in this study. Figure 2 provides statistical findings. Statistical analysis revealed no significant difference in ST shape distribution between OI1 and OI3 subtypes.
dc.description.sponsorshipSAMRC
dc.identifier.urihttps://hdl.handle.net/10566/20682
dc.language.isoen
dc.publisherUniversity of the Western Cape
dc.subjectRadiographic patterns
dc.subjectSella turcica shape
dc.subjectOsteogenesis
dc.subjectSouth Africa
dc.subjectCraniofacial assessment
dc.titleRadiographic patterns of sella turcica shape in osteogenesis imperfecta: A pilot study in a South African cohort
dc.typePresentation

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