A Panel of Ancestry Informative Markers for the Complex Five-Way Admixed South African Coloured Population

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dc.contributor.authorDaya, Michelle
dc.contributor.authorvan der Merwe, Lize
dc.contributor.authorGalal, Ushma
dc.contributor.authorMöller, Marlo
dc.contributor.authorSalie, Muneeb
dc.contributor.authorChimusa, Emile R.
dc.contributor.authorGalanter, Joshua M.
dc.contributor.authorvan Helden, Paul D.
dc.contributor.authorHenn, Brenna M.
dc.contributor.authorGignoux, Chris R.
dc.contributor.authorHoal, Eileen G.
dc.date.accessioned2017-07-10T10:03:35Z
dc.date.available2017-07-10T10:03:35Z
dc.date.issued2013
dc.description.abstractAdmixture is a well known confounder in genetic association studies. If genome-wide data is not available, as would be the case for candidate gene studies, ancestry informative markers (AIMs) are required in order to adjust for admixture. The predominant population group in the Western Cape, South Africa, is the admixed group known as the South African Coloured (SAC). A small set of AIMs that is optimized to distinguish between the five source populations of this population (African San, African non-San, European, South Asian, and East Asian) will enable researchers to cost-effectively reduce false-positive findings resulting from ignoring admixture in genetic association studies of the population. Using genome-wide data to find SNPs with large allele frequency differences between the source populations of the SAC, as quantified by Rosenberg et. al's -statistic, we developed a panel of AIMs by experimenting with various selection strategies. Subsets of different sizes were evaluated by measuring the correlation between ancestry proportions estimated by each AIM subset with ancestry proportions estimated using genome-wide data. We show that a panel of 96 AIMs can be used to assess ancestry proportions and to adjust for the confounding effect of the complex five-way admixture that occurred in the South African Coloured population.en_US
dc.description.accreditationDepartment of HE and Training approved list
dc.identifier.citationDaya, M. et al. (2013). A Panel of Ancestry Informative Markers for the Complex Five-Way Admixed South African Coloured Population. PLOS ONE, 8 (12): 1-11en_US
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10566/3059
dc.language.isoenen_US
dc.publisherPloSen_US
dc.rightsCopyright Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.source.urihttp://dx.doi.org/10.1371/journal.pone.0082224
dc.subjectSouth African Coloured Populationen_US
dc.subjectAdmixtureen_US
dc.subjectAncestry Informative Markersen_US
dc.subjectComplex Five-Wayen_US
dc.titleA Panel of Ancestry Informative Markers for the Complex Five-Way Admixed South African Coloured Populationen_US
dc.typeArticleen_US

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