The association of mthfr (rs1801133) with hypertension in an indigenous South African population

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dc.contributor.authorMabhida, Sihle E.
dc.contributor.authorSharma, Jyoti R.
dc.contributor.authorApalata, Teke
dc.date.accessioned2022-08-16T13:09:54Z
dc.date.available2022-08-16T13:09:54Z
dc.date.issued2022
dc.description.abstractThe current study sought to investigate the association between the methylenetetrahydrofolate reductase (MTHFR) variant (rs1801133) and the risk of developing hypertension (HTN) in an indigenous South African population.A total of 442 participants (hypertensive, n = 279 and nonhypertensive, n = 163) from the indigenous tribe residing in Mthatha, Eastern Cape (South Africa) were recruited. HTN was defined as a systolic (SBP) and diastolic blood pressure (DBP) of ≥130/80 mmHg following American Heart Association guidelines. The genotyping of MTHFR (rs1801133) was assessed using MassARRAY® System. Thereafter, the association between rs1801133 in various genetic models and HTN was determined by logistic regression model analysis. Furthermore, the interaction between rs1801133 and selected risk factors on HTN was performed using the open-source multifactor dimensionality reduction (MDR).en_US
dc.identifier.citationMabhida, S. E. et al. (2022). The association of mthfr (rs1801133) with hypertension in an indigenous South African population. Frontiers in Genetics, 13, 937639. https://doi.org/10.3389/fgene.2022.937639en_US
dc.identifier.issn1664-8021
dc.identifier.urihttps://doi.org/10.3389/fgene.2022.937639
dc.identifier.urihttp://hdl.handle.net/10566/7740
dc.language.isoenen_US
dc.publisherFrontiers Mediaen_US
dc.subjectHypertensionen_US
dc.subjectGenetic variationen_US
dc.subjectBiotechnologyen_US
dc.subjectAfricaen_US
dc.subjectMental disorderen_US
dc.titleThe association of mthfr (rs1801133) with hypertension in an indigenous South African populationen_US
dc.typeArticleen_US

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