The association of mthfr (rs1801133) with hypertension in an indigenous South African population
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers Media
Abstract
The current study sought to investigate the association between the
methylenetetrahydrofolate reductase (MTHFR) variant (rs1801133) and the risk
of developing hypertension (HTN) in an indigenous South African population.A total of 442 participants (hypertensive, n = 279 and nonhypertensive, n = 163) from the indigenous tribe residing in Mthatha, Eastern
Cape (South Africa) were recruited. HTN was defined as a systolic (SBP) and
diastolic blood pressure (DBP) of ≥130/80 mmHg following American Heart
Association guidelines. The genotyping of MTHFR (rs1801133) was assessed
using MassARRAY®
System. Thereafter, the association between rs1801133 in
various genetic models and HTN was determined by logistic regression model
analysis. Furthermore, the interaction between rs1801133 and selected risk
factors on HTN was performed using the open-source multifactor
dimensionality reduction (MDR).
Description
Keywords
Hypertension, Genetic variation, Biotechnology, Africa, Mental disorder
Citation
Mabhida, S. E. et al. (2022). The association of mthfr (rs1801133) with hypertension in an indigenous South African population. Frontiers in Genetics, 13, 937639. https://doi.org/10.3389/fgene.2022.937639