Bioassay guided fractionation of Angiotensin converting enzyme inhibitor compound from Hypericum perforatum

Simple item page
dc.contributor.advisorObikeze, Kenechukwu
dc.contributor.advisorBeukes, Denzil R.
dc.contributor.authorMokwelu, Onyinye Vivian
dc.date.accessioned2019-09-02T07:34:04Z
dc.date.accessioned2024-05-15T07:43:02Z
dc.date.available2019-09-02T07:34:04Z
dc.date.available2024-05-15T07:43:02Z
dc.date.issued2019
dc.descriptionMagister Pharmaceuticae - MPharmen_US
dc.description.abstractDue to the contribution of hypertension to various cardiovascular diseases, many studies are currently focused on identifying efficient bioactive compounds with antihypertensive activity and thus reducing the levels of cardiovascular disease. ACE inhibitors are an important component of the therapeutic regimen for treating hypertension, but due to the increase in the prevalence of side effects of synthetic compounds, alternative and complementary medicines which may consist of pure bioactive compound or a combination of various compounds from natural sources are gaining importance in overcoming hypertension. Hypericum perforatum has been studied for various activities including anti-bacterial, anti-depressant, anti-oxidant properties, but studies on its cardiovascular effects specifically ACE inhibitory activity have not yet been explored. In this study, ACEI assay-guided fractionation of the ethanol extract of Hypericum perforatum was carried out other to isolate a compound with ACE inhibition. A compound – (3-hydroxy 4, 4 dimethyl-4-butyrolactone) was isolated from an active fraction of the plant extract and was tested for ACE inhibition and its chemical structure elucidated using 1HNMR and C13NMR spectrometry and further characterized using mass spectrometry and FTIR.en_US
dc.identifier.urihttps://hdl.handle.net/10566/15180
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectBioassayen_US
dc.subjectHypericum perforatumen_US
dc.subjectSt John’s Worten_US
dc.subjectHypertensionen_US
dc.subjectAngiotensin converting enzyme inhibitoren_US
dc.titleBioassay guided fractionation of Angiotensin converting enzyme inhibitor compound from Hypericum perforatumen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
mokwelu_m_nsc_2019.pdf
Size:
5.62 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Plain Text
Description:
Download

Collections

Magister Pharmaceuticae - MPharm