Marrubiin

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dc.contributor.advisorPopoola, Olugbenga K.
dc.contributor.advisorElbagory, Abdulrahman M.
dc.contributor.advisorAmeer, Farouk
dc.contributor.advisorHussein, Ahmed A.
dc.date.accessioned2017-01-30T13:38:20Z
dc.date.available2017-01-30T13:38:20Z
dc.date.issued2013
dc.description.abstractThe ethno-medicinal approach to drug discovery represents one of the most important sources of new and safe therapeutic agents to the challenges confronting modern medicine and daily life. Many of the traditionally important medicinal plants contain active molecules or ones that serve as precursors to biosynthesised secondary metabolites to which the biological activity could be attributed. Marrubiin is one such compound and is a potential valuable compound which exists in high concentrations in many traditionally important Lamiaceae species which have demonstrated excellent pharmacological properties with commendably high safety margins. Marrubiin's attributes include a low turnover, high stability and little catabolism, which are core characteristics required for therapeutic compounds and nutraceuticals of economic importance. In addition, marrubiin is considered a potential substrate for potent active compounds viz; marrubiinic acid, and marrubenol. The contribution of marrubiin to drug discovery thus needs to be put into prospective due to its ready availability, high potential applications and ease of modification. In this short review we highlight the most important chemical and pharmacological aspects reported on marrubiin since it was discovered.en_US
dc.identifier.citationPopoola, O.K. et al. (2013). Marrubiin. Molecules, 18: 9049-9060en_US
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10566/2505
dc.identifier.urihttp://dx.doi.org/10.3390/molecules18089049
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rightsAll articles published by MDPI are made immediately available worldwide under an open access license
dc.subjectMarrubiinen_US
dc.subjectLamiaceaeen_US
dc.subjectBiological activityen_US
dc.subjectLead compounden_US
dc.subjectAnti-inflammatoryen_US
dc.titleMarrubiinen_US
dc.typeArticleen_US

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