Marrubiin
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Date
2013
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
The ethno-medicinal approach to drug discovery represents one of the most
important sources of new and safe therapeutic agents to the challenges confronting modern
medicine and daily life. Many of the traditionally important medicinal plants contain active
molecules or ones that serve as precursors to biosynthesised secondary metabolites to
which the biological activity could be attributed. Marrubiin is one such compound and is a
potential valuable compound which exists in high concentrations in many traditionally
important Lamiaceae species which have demonstrated excellent pharmacological
properties with commendably high safety margins. Marrubiin's attributes include a low
turnover, high stability and little catabolism, which are core characteristics required for
therapeutic compounds and nutraceuticals of economic importance. In addition, marrubiin
is considered a potential substrate for potent active compounds viz; marrubiinic acid, and
marrubenol. The contribution of marrubiin to drug discovery thus needs to be put into
prospective due to its ready availability, high potential applications and ease of
modification. In this short review we highlight the most important chemical and
pharmacological aspects reported on marrubiin since it was discovered.
Description
Keywords
Marrubiin, Lamiaceae, Biological activity, Lead compound, Anti-inflammatory
Citation
Popoola, O.K. et al. (2013). Marrubiin. Molecules, 18: 9049-9060