Changes in subcutaneous adipose tissue microRNA expression in response to exercise training in African women with obesity
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Nature Research
Abstract
The mechanisms that underlie exercise-induced adaptations in adipose tissue have not been
elucidated, yet, accumulating studies suggest an important role for microRNAs (miRNAs). This study
aimed to investigate miRNA expression in gluteal subcutaneous adipose tissue (GSAT) in response to
a 12-week exercise intervention in South African women with obesity, and to assess depot-specific
differences in miRNA expression in GSAT and abdominal subcutaneous adipose tissue (ASAT). In
addition, the association between exercise-induced changes in miRNA expression and metabolic risk
was evaluated. Women underwent 12-weeks of supervised aerobic and resistance training (n = 19) or
maintained their regular physical activity during this period (n = 12). Exercise-induced miRNAs were
identified in GSAT using Illumina sequencing, followed by analysis of differentially expressed miRNAs
in GSAT and ASAT using quantitative real-time PCR. Associations between the changes (pre- and postexercise
training) in miRNA expression and metabolic parameters were evaluated using Spearman’s
correlation tests.
Description
Keywords
Obesity, Public health, Africa, Women, Type 2 diabetes
Citation
Pheiffer, C. et al. (2023). Changes in subcutaneous adipose tissue microRNA expression in response to exercise training in African women with obesity. Scientific Reports, 12(1), 18408. 10.1038/s41598-022-23290-x