Protein interaction networks as metric spaces: A novel perspective on distribution of hubs

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dc.contributor.authorFadhal, Emad
dc.contributor.authorGamieldien, Junaid
dc.contributor.authorMwambene, Eric C
dc.date.accessioned2023-03-02T11:53:56Z
dc.date.available2023-03-02T11:53:56Z
dc.date.issued2014
dc.description.abstractIn the post-genomic era, a central and overarching question in the analysis of protein-protein interaction networks continues to be whether biological characteristics and functions of proteins such as lethality, physiological malfunctions and malignancy are intimately linked to the topological role proteins play in the network as a mathematical structure. One of the key features that have implicitly been presumed is the existence of hubs, highly connected proteins considered to play a crucial role in biological networks. We explore the structure of protein interaction networks of a number of organisms as metric spaces and show that hubs are non randomly positioned and, from a distance point of view, centrally located.en_US
dc.identifier.citationFadhal, E. et al. (2014). Protein interaction networks as metric spaces: A novel perspective on distribution of hubs. BMC Systems Biology, , 8(6). https://doi.org/10.1186/1752-0509-8-6en_US
dc.identifier.issn1752-0509
dc.identifier.urihttps://doi.org/10.1186/1752-0509-8-6
dc.identifier.urihttp://hdl.handle.net/10566/8513
dc.language.isoenen_US
dc.publisherBMCen_US
dc.subjectApplied Mathematicsen_US
dc.subjectProteinen_US
dc.subjectMetric spacesen_US
dc.subjectHubsen_US
dc.titleProtein interaction networks as metric spaces: A novel perspective on distribution of hubsen_US
dc.typeArticleen_US

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