Protein interaction networks as metric spaces: A novel perspective on distribution of hubs
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Date
2014
Journal Title
Journal ISSN
Volume Title
Publisher
BMC
Abstract
In the post-genomic era, a central and overarching question in the analysis of protein-protein
interaction networks continues to be whether biological characteristics and functions of proteins such as lethality,
physiological malfunctions and malignancy are intimately linked to the topological role proteins play in the network
as a mathematical structure. One of the key features that have implicitly been presumed is the existence of hubs,
highly connected proteins considered to play a crucial role in biological networks. We explore the structure of protein
interaction networks of a number of organisms as metric spaces and show that hubs are non randomly positioned
and, from a distance point of view, centrally located.
Description
Keywords
Applied Mathematics, Protein, Metric spaces, Hubs
Citation
Fadhal, E. et al. (2014). Protein interaction networks as metric spaces: A novel perspective on distribution of hubs. BMC Systems Biology, , 8(6). https://doi.org/10.1186/1752-0509-8-6