Carcinoembryonic antigen immunosensor developed with organoclay nanogold composite film

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dc.contributor.authorKemmegne-Mbouguen, Justin Claude
dc.contributor.authorNgameni, Emmanuel
dc.contributor.authorBaker, Priscilla
dc.contributor.authorWaryo, Tesfaye T.
dc.contributor.authorKgarebe, Boitumelo
dc.contributor.authorIwuoha, Emmanuel I.
dc.date.accessioned2017-12-01T13:44:12Z
dc.date.available2017-12-01T13:44:12Z
dc.date.issued2014
dc.description.abstractOrganoclay nanogold composite were prepared using gold nanoparticles and the natural Cameroonian clay grafted with amino organosilane. The functionnalization of clay provided abundant amino group to assemble gold nanoparticles. A label-free electrochemical immunosensor for the sensitive determination of carcinoembryonic antigen (CEA) was fabricated by immobilizing anti-CEA onto organoclay nanogold composite film modified electrode by the cross-linking method using glutaraldehyde. In addition, the preparation procedure of the immunosensor was investigated by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Under optimal conditions, the resulting immunosensor displayed a high sensitivity for the detection of CEA, and responded to the CEA concentration in two ranges from 0.05 to 5.0 ng/mL (R = 0.991) and from 5.0 to 120.0 ng/mL (R = 0.998) with a detection limit of 0.01 ng/mL.en_US
dc.identifier.citationKemmegne-Mbouguen, J.C. et al. (2014). Carcinoembryonic antigen immunosensor developed with organoclay nanogold composite film. International Journal of Electrochemical Science, 9: 478 - 492en_US
dc.identifier.issn1452-3981
dc.identifier.urihttp://hdl.handle.net/10566/3292
dc.language.isoenen_US
dc.privacy.showsubmitterFALSE
dc.publisherESGen_US
dc.rightsInternational Journal of Electrochemical Science (ISSN 1452-3981) is international peer-reviewed and open access journal
dc.status.ispeerreviewedTRUE
dc.subjectOrganoclayen_US
dc.subjectNanogold compositeen_US
dc.subjectModified electrodeen_US
dc.subjectImmunosenoren_US
dc.subjectCarcinoembryonic antigenen_US
dc.titleCarcinoembryonic antigen immunosensor developed with organoclay nanogold composite filmen_US
dc.typeArticleen_US

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