4-Oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione Derivatives as NMDA Receptor- and VGCC Blockers with Neuroprotective Potential

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dc.contributor.authorEgunlusi, A
dc.contributor.authorMalan, S
dc.contributor.authorOmoruyi, S
dc.date.accessioned2021-09-01T15:28:28Z
dc.date.available2021-09-01T15:28:28Z
dc.date.issued2020
dc.description.abstractThe impact of excitotoxicity mediated by N-methyl-D-aspartate (NMDA) receptor overactivation and voltage gated calcium channel (VGCC) depolarization is prominent among the postulated processes involved in the development of neurodegenerative disorders. NGP1-01, a polycyclic amine, has been shown to be neuroprotective through modulation of the NMDA receptor and VGCC, and attenuation of MPP+-induced neurotoxicity. Recently, we reported on the calcium modulating effects of tricycloundecene derivatives, structurally similar to NGP1-01, on the NMDA receptor and VGCC of synaptoneurosomes.en_US
dc.identifier.citationEgunlusi, A.O.; Malan, S.F.; Omoruyi, S.I.; Ekpo, O.E.; Joubert, J. 4-Oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione Derivatives as NMDA Receptor- and VGCC Blockers with Neuroprotective Potential. Molecules 2020, 25, 4552. https://doi.org/10.3390/molecules25194552en_US
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10566/6590
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectNeurodegenerative disordersen_US
dc.subject4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dioneen_US
dc.subjectCytotoxicityen_US
dc.subjectNeuroprotectionen_US
dc.subjectNMDA receptoren_US
dc.title4-Oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione Derivatives as NMDA Receptor- and VGCC Blockers with Neuroprotective Potentialen_US
dc.typeArticleen_US

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