4-Oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione Derivatives as NMDA Receptor- and VGCC Blockers with Neuroprotective Potential
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Date
2020
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
The impact of excitotoxicity mediated by N-methyl-D-aspartate (NMDA) receptor
overactivation and voltage gated calcium channel (VGCC) depolarization is prominent among
the postulated processes involved in the development of neurodegenerative disorders. NGP1-01,
a polycyclic amine, has been shown to be neuroprotective through modulation of the NMDA
receptor and VGCC, and attenuation of MPP+-induced neurotoxicity. Recently, we reported on
the calcium modulating effects of tricycloundecene derivatives, structurally similar to NGP1-01,
on the NMDA receptor and VGCC of synaptoneurosomes.
Description
Keywords
Neurodegenerative disorders, 4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione, Cytotoxicity, Neuroprotection, NMDA receptor
Citation
Egunlusi, A.O.; Malan, S.F.; Omoruyi, S.I.; Ekpo, O.E.; Joubert, J. 4-Oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione Derivatives as NMDA Receptor- and VGCC Blockers with Neuroprotective Potential. Molecules 2020, 25, 4552. https://doi.org/10.3390/molecules25194552