Synthesis of new biguanide derivatives as potential antidiabetic drugs

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dc.contributor.advisorTitinchi, Salam
dc.contributor.authorSalubi, Christiana Abimbola
dc.date.accessioned2022-08-12T12:59:50Z
dc.date.accessioned2024-05-13T12:40:33Z
dc.date.available2024-05-13T12:40:33Z
dc.date.issued2022
dc.descriptionPhilosophiae Doctor - PhDen_US
dc.description.abstractThe main purpose of this study was to synthesize biguanide compounds with potential as antidiabetic drugs. All biguanide compounds possess antidiabetic properties by decreasing the blood glucose level. Hence, we embarked on the synthesis of a series of biguanides in a threestep reaction which involves synthesis of a Schiff base, reduction of the Schiff base to a secondary amine using sodium borohydride and lastly formation of substituted biguanide derivatives with amines (primary or secondary) and dicyandiamide.en_US
dc.description.embargo2025
dc.identifier.urihttps://hdl.handle.net/10566/14700
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectDicyandiamideen_US
dc.subjectBiguanideen_US
dc.subjectDiabetesen_US
dc.subjectAntidiabetic drugsen_US
dc.subjectChemistryen_US
dc.titleSynthesis of new biguanide derivatives as potential antidiabetic drugsen_US

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