Synthesis of new biguanide derivatives as potential antidiabetic drugs
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Date
2022
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
University of the Western Cape
Abstract
The main purpose of this study was to synthesize biguanide compounds with potential as
antidiabetic drugs. All biguanide compounds possess antidiabetic properties by decreasing the
blood glucose level. Hence, we embarked on the synthesis of a series of biguanides in a threestep
reaction which involves synthesis of a Schiff base, reduction of the Schiff base to a
secondary amine using sodium borohydride and lastly formation of substituted biguanide
derivatives with amines (primary or secondary) and dicyandiamide.
Description
Philosophiae Doctor - PhD
Keywords
Dicyandiamide, Biguanide, Diabetes, Antidiabetic drugs, Chemistry