Human coronavirus NL63: A clinically important virus?

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dc.contributor.authorFielding, Burtram C
dc.date.accessioned2023-03-03T09:03:53Z
dc.date.available2023-03-03T09:03:53Z
dc.date.issued2011
dc.description.abstractRespiratory tract infection is a leading cause of morbidity and mortality worldwide, especially among young children. Human coronaviruses (HCoVs) have only recently been shown to cause both lower and upper respiratory tract infections. To date, five coronaviruses (HCoV-229E, HCoV-OC43, SARS-CoV, HCoV-NL63 and HCoV HKU-1) that infect humans have been identified, four of which (HCoV-229E, HCoV-OC43, HCoV-NL63 and HCoV-HKU-1) circulate continuously in the human population. Human coronavirus NL63 (HCoV-NL63) was first isolated from the aspirate from a 7-month-old baby in early 2004. Infection with HCoV-NL63 has since been shown to be a common worldwide occurrence and has been associated with many clinical symptoms and diagnoses, including severe lower respiratory tract infection, croup and bronchiolitis. HCoV-NL63 causes disease in children, the elderly and the immunocompromised, and has been detected in 1.0–9.3% of respiratory tract infections in children. In this article, the current knowledge of human coronavirus HCoV-NL63, with special reference to the clinical features, prevalence and seasonal incidence, and coinfection with other respiratory viruses, will be discussed.en_US
dc.identifier.citationFielding, B. C. (2011). Human coronavirus NL63: A clinically important virus?. Future Microbiology, 6 (2) , 153-159. https://doi.org/10.2217/fmb.10.166en_US
dc.identifier.issn1746-0921
dc.identifier.urihttps://doi.org/10.2217/fmb.10.166
dc.identifier.urihttp://hdl.handle.net/10566/8522
dc.language.isoenen_US
dc.publisherFuture Science Groupen_US
dc.subjectCovid-19en_US
dc.subjectPublic healthen_US
dc.subjectBioscienceen_US
dc.subjectMortalityen_US
dc.subjectYoung childrenen_US
dc.titleHuman coronavirus NL63: A clinically important virus?en_US
dc.typeArticleen_US

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