Polymorphisms of androgens-related genes and idiopathic male infertility in Turkish men

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dc.contributor.authorMahmutoglu, A
dc.contributor.authorDirie, S
dc.contributor.authorHenkel, R
dc.date.accessioned2022-08-04T20:42:14Z
dc.date.available2022-08-04T20:42:14Z
dc.date.issued2021
dc.description.abstractAndrogens, testosterone and dihydrotestosterone (DHT) are endocrine regulators of spermatogenesis and act via androgen receptor (AR). The aim of this study was to investigate the association(s) of AR (CAG repeat length), SRD5A2 (rs523349, V89L) and TNF-α (rs1800629, -308G/A) polymorphisms with idiopathic male infertility in Turkish men. This case-control study consisted of 312 men with idiopathic infertility and 113 fertile men. Polyacrylamide gel electrophoresis (PAGE) or PCR-restriction fragment length polymorphism methods were used for genotyping. The mean AR CAG repeat length was significantly longer in infertile men than in fertile men (p = 0.015). However, there was no significant association between the SRD5A2 genotypes (VV, VL and LL) and the risk of infertility (p = 0.516). The genotype frequency and allele distribution of TNF-α -308G/A polymorphism (GG, GA, AA genotypes and G, A alleles) were not associated with male infertility (p = 0.779 and p = 0.743 respectively). AR CAG repeat expansion might be one of the risk factors for idiopathic male infertility in Turkish men. Further studies investigating the association of male infertility with AR CAG, V89L and -308G/A polymorphisms are warranted to understand the possible associations among them.en_US
dc.identifier.citationMetin Mahmutoglu, Asli et al. “Polymorphisms of Androgens‐related Genes and Idiopathic Male Infertility in Turkish Men.” Andrologia 54.2 (2022): e14270–n/a. Web.en_US
dc.identifier.issn0303-4569
dc.identifier.uriDOI: 10.1111/and.14270
dc.identifier.urihttp://hdl.handle.net/10566/7696
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectAR CAG repeat lengthen_US
dc.subjectmale infertilityen_US
dc.subjectSRD5Aen_US
dc.subjectTNF-αen_US
dc.titlePolymorphisms of androgens-related genes and idiopathic male infertility in Turkish menen_US
dc.typeArticleen_US

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