Polymorphisms of androgens-related genes and idiopathic male infertility in Turkish men
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Date
2021
Authors
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Journal ISSN
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Publisher
Wiley
Abstract
Androgens, testosterone and dihydrotestosterone (DHT) are endocrine regulators of
spermatogenesis and act via androgen receptor (AR). The aim of this study was to investigate the association(s) of AR (CAG repeat length), SRD5A2 (rs523349, V89L) and
TNF-α (rs1800629, -308G/A) polymorphisms with idiopathic male infertility in Turkish
men. This case-control study consisted of 312 men with idiopathic infertility and
113 fertile men. Polyacrylamide gel electrophoresis (PAGE) or PCR-restriction fragment length polymorphism methods were used for genotyping. The mean AR CAG
repeat length was significantly longer in infertile men than in fertile men (p = 0.015).
However, there was no significant association between the SRD5A2 genotypes (VV,
VL and LL) and the risk of infertility (p = 0.516). The genotype frequency and allele
distribution of TNF-α -308G/A polymorphism (GG, GA, AA genotypes and G, A alleles) were not associated with male infertility (p = 0.779 and p = 0.743 respectively).
AR CAG repeat expansion might be one of the risk factors for idiopathic male infertility in Turkish men. Further studies investigating the association of male infertility
with AR CAG, V89L and -308G/A polymorphisms are warranted to understand the
possible associations among them.
Description
Keywords
AR CAG repeat length, male infertility, SRD5A, TNF-α
Citation
Metin Mahmutoglu, Asli et al. “Polymorphisms of Androgens‐related Genes and Idiopathic Male Infertility in Turkish Men.” Andrologia 54.2 (2022): e14270–n/a. Web.