Polycyclic compounds as carriers for neuroactive non- steroidal anti-inflammatory drugs

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dc.contributor.advisorJoubert, Jacques
dc.contributor.authorAbaniwonda, Modupe
dc.date.accessioned2018-02-07T10:22:04Z
dc.date.accessioned2024-05-15T07:42:51Z
dc.date.available2018-02-07T10:22:04Z
dc.date.available2024-05-15T07:42:51Z
dc.date.issued2017
dc.descriptionMagister Pharmaceuticae - MPharmen_US
dc.description.abstractRecent scientific findings have highlighted the beneficial roles of polycyclic cage compounds in neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Further interest into the chemistry of these compounds is stimulated by their remarkable ability to improve the pharmacokinetics profile of known neuroprotective agents. As potent lipophilic scaffolds, they can be employed to target the brain delivery of desired compounds. Inflammation is a key mediator of neuronal cell's degeneration as activated microglia and other inflammatory mediators propagate oxidative damage and neuronal loss. Epidemiological and clinical evidence suggests that non-steroidal anti-inflammatory drugs (NSAIDs) slow down the progression and onset of neurodegenerative diseases. The beneficial effects of NSAIDs in ND can be attributed to their ability to inhibit cyclooxygenase enzymes thereby halting the biosynthesis of prostaglandins (PG) which are powerful mediators of inflammation. NSAIDs also inhibit the expression of pro- inflammatory genes. Despite their potential neuroprotective activity, NSAIDs are poorly lipophilic due to the presence of polar carboxylic acid groups and will therefore ionise at physiological pH, deterring them from reaching the desired site of action in the central nervous system (CNS).en_US
dc.identifier.urihttps://hdl.handle.net/10566/15147
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectNeurodegenerative disordersen_US
dc.subjectOxidative stressen_US
dc.subjectExcitotoxicityen_US
dc.subjectPolycyclic cage compoundsen_US
dc.subjectBlood-brain barrieren_US
dc.titlePolycyclic compounds as carriers for neuroactive non- steroidal anti-inflammatory drugsen_US

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